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Article

Interaction model for anthracycline activity against DNA topoisomerase II.

Biochemistry - 15 Jun 2004

Moro Stefano, Beretta Giovanni L, Dal Ben Diego, Nitiss John, Palumbo Manlio, Capranico Giovanni

Abstract excerpt

DNA topoisomerase II (Top2) is an essential nuclear enzyme and a target of very effective anticancer drugs including anthracycline antibiotics. Even though several aspects of drug activity against Top2 are understood, the drug receptor site is not yet known. Several Top2 mutants have altered drug sensitivity and have provided information of structural features determining drug action. Here, we have investigated...

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PMID: 15182192
DOI: 10.1021/bi0361665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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