The top2-5 mutant of yeast topoisomerase II encodes an enzyme resistant to etoposide and amsacrine.

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Article

The top2-5 mutant of yeast topoisomerase II encodes an enzyme resistant to etoposide and amsacrine.

The Journal of biological chemistry - 5 Sept 1993

Jannatipour M, Liu Y X, Nitiss J L

Abstract excerpt

We have characterized a temperature-sensitive mutant in the yeast TOP2 gene that shows resistance to the anti-topoisomerase II agents amsacrine and etoposide. Cells carrying the top2-5 mutant have a minimum lethal concentration of amsacrine of greater than 100 micrograms/ml, compared to 10 microg...

Topics

Alleles
Amino Acid Sequence
Amsacrine
Antineoplastic Agents
Base Sequence
Cloning, Molecular
DNA Topoisomerases, Type II
DNA, Fungal
Drug Resistance, Microbial
Etoposide
Kinetics
Molecular Sequence Data
Mutation
Saccharomyces cerevisiae
Temperature
Topoisomerase II Inhibitors

Source

Open in PubMed

Identifiers

PMID: 8395511

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8395511-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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