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The top2-5 mutant of yeast topoisomerase II encodes an enzyme resistant to etoposide and amsacrine.

The Journal of biological chemistry - 5 Sept 1993

Jannatipour M, Liu Y X, Nitiss J L

Abstract excerpt

We have characterized a temperature-sensitive mutant in the yeast TOP2 gene that shows resistance to the anti-topoisomerase II agents amsacrine and etoposide. Cells carrying the top2-5 mutant have a minimum lethal concentration of amsacrine of greater than 100 micrograms/ml, compared to 10 micrograms/ml in isogenic wild-type cells, and a minimum lethal concentration of greater than 100 micrograms/ml etoposide,...

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PMID: 8395511

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The top2-5 mutant of yeast topoisomerase II encodes an enzyme resistant to etoposide and amsacrine.PMID 8395511Read ↗

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