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Targeting DNA Topoisomerase II in Antifungal Chemotherapy

11 Nov 2022

Abstract excerpt

Topoisomerase inhibitors have been in use clinically for the treatment of several diseases for decades. Although those enzymes are significant molecular targets in antibacterial and anticancer chemotherapy very little is known about the possibilities to target fungal topoisomerase II (topo II). Raising concern for the fungal infections, lack of effective drugs and a phenomenon of multidrug resistance underlie a...

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PMID: 36431868
DOI: 10.3390/molecules27227768

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