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Article

Allele specific synthetic lethality between priC and dnaAts alleles at the permissive temperature of 30 degrees C in E. coli K-12.

BMC microbiology - 8 Dec 2004

Hinds Tania, Sandler Steven J

Abstract excerpt

BACKGROUND: DnaA is an essential protein in the regulation and initiation of DNA replication in many bacteria. It forms a protein-DNA complex at oriC to which DnaC loads DnaB. DNA replication forks initiated at oriC by DnaA can collapse on route to the terminus for a variety of reasons. PriA, PriB, PriC, DnaT, Rep and DnaC form multiple pathways to restart repaired replication forks. DnaC809 and dnaC809,820 are...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15588282
DOI: 10.1186/1471-2180-4-47
PMCID: PMC539235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Allele specific synthetic lethality between priC and dnaAts alleles at the permissive temperature of 30 degrees C in E. coli K-12.PMID 15588282Read ↗

A novel dnaC mutation that suppresses priB rep mutant phenotypes in Escherichia coli K-12.Semantic proximity Read ↗

Multiple genetic pathways for restarting DNA replication forks in Escherichia coli K-12.Semantic proximity Read ↗

PriA mutations that affect PriA-PriC function during replication restart.Semantic proximity Read ↗

dnaC mutations suppress defects in DNA replication- and recombination-associated functions in priB and priC double mutants in Escherichia coli K-12.Semantic proximity Read ↗

Escherichia coli K-12 has two distinguishable PriA-PriB replication restart pathways.Semantic proximity Read ↗

A dnaT mutant with phenotypes similar to those of a priA2::kan mutant in Escherichia coli K-12.Semantic proximity Read ↗

Mutational Analysis of Residues in PriA and PriC Affecting Their Ability To Interact with SSB in Escherichia coli K-12.Semantic proximity Read ↗

The DNA replication priming protein, PriA, is required for homologous recombination and double-strand break repair.Semantic proximity Read ↗

Requirements for replication restart proteins during constitutive stable DNA replication in Escherichia coli K-12.Semantic proximity Read ↗

Escherichia coli PriA protein is essential for inducible and constitutive stable DNA replication.Semantic proximity Read ↗

Differential suppression of priA2::kan phenotypes in Escherichia coli K-12 by mutations in priA, lexA, and dnaC.Semantic proximity Read ↗

ATPase-deficient mutants of the Escherichia coli DNA replication protein PriA are capable of catalyzing the assembly of active primosomes.Semantic proximity Read ↗

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