Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glucuronidation of acetaminophen is independent of UGT1A1 promotor genotype.

International journal of clinical pharmacology and therapeutics - 1 Feb 2004

Rauchschwalbe S K, Zühlsdorf M T, Wensing G, Kuhlmann J

Abstract excerpt

The metabolism of acetaminophen (paracetamol) is thought to be altered in patients with Gilbert's syndrome (GS), a chronic unconjugated hyperbilirubinemia. The underlying cause of GS is a polymorphism in the promotor region of the uridine diphosphate glucuronosyltransferase isoform 1A1 gene (UGT1A1*28), its encoded enzyme being responsible for the glucuronidation of bilirubin and presumably acetaminophen....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetaminophen
Share to Administration, Oral
Share to Analgesics, Non-Narcotic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bilirubin

Share to Gilbert Disease

Share to Glucuronosyltransferase

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 15180166
DOI: 10.5414/cpp42073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glucuronidation of acetaminophen is independent of UGT1A1 promotor genotype.PMID 15180166Read ↗

The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failure.Semantic proximity Read ↗

Effect of UDP-Glucuronosyltransferase (UGT) 1A Polymorphism (rs8330 and rs10929303) on Glucuronidation Status of AcetaminophenSemantic proximity Read ↗

Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure.Semantic proximity Read ↗

Paracetamol metabolism and related genetic differences.Semantic proximity Read ↗

Combined polymorphisms in UDP-glucuronosyltransferases 1A1 and 1A6: implications for patients with Gilbert's syndrome.Semantic proximity Read ↗

Tissue distribution and interindividual variation in human UDP-glucuronosyltransferase activity: relationship between UGT1A1 promoter genotype and variability in a liver bank.Semantic proximity Read ↗

Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9).Semantic proximity Read ↗

Biotransformation and toxicity of acetaminophen in congenic RHA rats with or without a hereditary deficiency in bilirubin UDP-glucuronosyltransferase.Semantic proximity Read ↗

Acetaminophen administration in a patient with Gilbert's syndrome.Semantic proximity Read ↗

UGT1A6 and UGT2B15 polymorphisms and acetaminophen conjugation in response to a randomized, controlled diet of select fruits and vegetables.Semantic proximity Read ↗

Study of the genetic determinants of UGT1A1 inducibility by phenobarbital in cultured human hepatocytes.Semantic proximity Read ↗

Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.