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Article

Study of the genetic determinants of UGT1A1 inducibility by phenobarbital in cultured human hepatocytes.

Pharmacogenetics and genomics - 1 Feb 2006

Ramírez Jacqueline, Komoroski Bernard J, Mirkov Snezana, Graber Andrea Yoder, Fackenthal Donna Lee, Schuetz Erin G, Das Soma, Ratain Mark J, Innocenti Federico, Strom Stephen C

Abstract excerpt

UGT1A1 is induced by phenobarbital. We investigated whether three common UGT1A1 variants are associated with the variability in UGT1A1 inducibility. Human hepatocytes were incubated with 2 mM phenobarbital for 2 and 6 days followed by 5 microM SN-38 (1 h), a UGT1A1 probe. SN-38 glucuronidation in the cell media was measured by high-performance liquid chromatography. Three UGT1A1 promoter variants [-53(TA)(6>7),...

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PMID: 16424820
DOI: 10.1097/01.fpc.0000182784.77630.48

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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