Article
Acetaminophen administration in a patient with Gilbert's syndrome.
Pediatrics international : official journal of the Japan Pediatric Society - 1 Dec 2012
Nakagawa Taku, Mure Takeo, Yusoff Surini, Ono Eiichi, Harahap Indra Sari Kusuma, Morikawa Satoru, Morioka Ichiro, Takeshima Yasuhiro, Nishio Hisahide, Matsuo Masafumi
Abstract excerpt
The patient was an 8-year-old Japanese girl with Gilbert's syndrome (GS). Based on the DNA analysis, she was homozygous for a T-to-G transversion at nucleotide position 1456 in the UGT1A1 gene, leading to the substitution of aspartate for tyrosine at position 486 of the UGT1A1 enzyme. Because this mutation is located in an exon common to UGT1A genes, all the UGT1A enzymes may be affected. It is well-known that...
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