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Article

Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility.

The Journal of biological chemistry - 2 Jul 2004

Schuh Kai, Cartwright Elizabeth J, Jankevics Eriks, Bundschu Karin, Liebermann Jürgen, Williams Judith C, Armesilla Angel L, Emerson Michael, Oceandy Delvac, Knobeloch Klaus-Peter, Neyses Ludwig

Abstract excerpt

Calcium and Ca(2+)-dependent signals play a crucial role in sperm motility and mammalian fertilization, but the molecules and mechanisms underlying these Ca(2+)-dependent pathways are incompletely understood. Here we show that homozygous male mice with a targeted gene deletion of isoform 4 of the plasma membrane calcium/calmodulin-dependent calcium ATPase (PMCA), which is highly enriched in the sperm tail, are...

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PMID: 15078889
DOI: 10.1074/jbc.M312599200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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