Plasma membrane Ca²⁺-ATPase 4: interaction with constitutive nitric oxide synthases in human sperm and prostasomes which carry Ca²⁺/CaM-dependent serine kinase

Abstract excerpt

Deletion of the gene encoding the widely conserved plasma membrane calcium ATPase 4 (PMCA4), a major Ca(2+) efflux pump, leads to loss of sperm motility and male infertility in mice. PMCA4's partners in sperm and how its absence exerts its effect on fertility are unknown. We hypothesize that in sperm PMCA4 interacts with endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) which are...

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