Article
Transcriptional control of TFF3 (intestinal trefoil factor) via promoter binding sites for the nuclear factor kappaB and C/EBPbeta.
Peptides - 1 May 2004
Baus-Loncar Mirela, Al-azzeh Ezzal-din, Romanska Hanna, Lalani El-Nasir, Stamp Gordon W H, Blin Nikolaus, Kayademir Tuncay
Abstract excerpt
The acute phase response is strictly connected with modulation of gene expression. Transcriptional control of many genes is mediated by binding of diverse transcription factors to cis-acting DNA motifs in the respective promoter sequence. We now describe such regulatory elements for the TFF3 gene coding for a peptide involved in response to gut irritation. TNF-alpha stimulation, which induces NF-kappaB...
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