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Article

Down-regulation of <i>TFF</i> Expression in Gastrointestinal Cell Lines by Cytokines and Nuclear Factors

1 Jan 2002

Abstract excerpt

BACKGROUND AND AIMS: Trefoil peptides (TFF1, TFF2 and TFF3) are acute phase proteins up-regulated in response to gastrointestinal mucosal damage. They promote cell migration, protect and heal the mucosa and may function as tumorsuppressors. We assumed them to be regulated by the proinflammatory cytokines interleukin-1beta (IL1beta) and interleukin-6 (IL6), which trigger the transcriptional factors NF-kappaB and...

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Identifiers

PMID: 12297725
DOI: 10.1159/000066279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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