Article
Relevance of glutathione S-transferase M1 and cytochrome P450 1A1 genetic polymorphisms to the development of head and neck cancers.
Clinical chemistry and laboratory medicine - 1 Jan 2008
Reszka Edyta, Czekaj Piotr, Adamska Jolanta, Wasowicz Wojciech
Abstract excerpt
BACKGROUND: Cytochrome P450 (CYP) and glutathione S-transferase (GST) gene variants have been intensively investigated for their implication in the development of different neoplasms. METHODS: In the present study, we analyzed genetic polymorphisms of CYP1A1, GSTM1, GSTP1, and GSTT1 in 127 head and neck cancer patients and 151 hospital controls. RESULTS: No significant increase in risk in patients with the GSTM1...
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