Article
Involvement of nitric oxide in angiogenic activities of vascular endothelial growth factor isoforms.
Growth factors (Chur, Switzerland) - 1 Mar 2004
Józkowicz Alicja, Dulak Józef, Nigisch Anneliese, Funovics Philipp, Weigel Guenter, Polterauer Peter, Huk Ihor, Malinski Tadeusz
Abstract excerpt
We compared effects of vascular endothelial growth factor-121 (VEGF121) and vascular endothelial growth factor-165 (VEGF165) on generation of NO in HUVEC and the involvement of NO in VEGF121- and VEGF165-induced angiogenesis. VEGF stimulated synthesis of NO within seconds, reaching peak concentrations of 450 +/- 25 and 180 +/- 15 nmol/l for VEGF121, and VEGF165, respectively. The VEGF121 increased NO production...
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