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Article

Neuropilin-1 and neuropilin-2 enhance VEGF121 stimulated signal transduction by the VEGFR-2 receptor.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2007

Shraga-Heled Niva, Kessler Ofra, Prahst Claudia, Kroll Jens, Augustin Hellmut, Neufeld Gera

Abstract excerpt

The neuropilin-1 (np1) receptor binds the 165 amino-acid form of vascular endothelial growth factor165 (VEGF165) and functions as an enhancer that potentiates VEGF165 signaling via the VEGFR-2 tyrosine-kinase receptor. To study the mechanism by which neuropilins potentiate VEGF activity we produced a VEGF165 mutant (VEGF165KF) that binds to neuropilins but displays a much lower affinity toward VEGFR-1 and...

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Identifiers

PMID: 17185751
DOI: 10.1096/fj.06-6277com

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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