Article
[Allelic distribution of the CYP1A1 in lung cancer patients, middle-aged tissue donors and in elderly people without cancer].
Voprosy onkologii - 1 Jan 2004
Belogubova E V, Togo A V, Suvorova I K, Karpova M B, Ulybina Iu M, Zaĭtseva O A, Iatsuk O S, Shutkin V A, Riabokon' S A, Ievleva A G, Chekmarëva E V, Lemekhov V G, Koloskov A V, Kuchinskiĭ A P, Khanson K P, Imianitov E N
Abstract excerpt
The genetic polymorphism of metabolizers of tobacco smoke carcinogens can influence individual susceptibility to lung cancer. The study was concerned with the Mspl-polymorphism of the CYP1A1 gene responsible for encoding aryl hydrocarbon hydroxylase. It also plays a role in the activation of polycyclic aromatic hydrocarbons (PAH). The CYP1A1 alleles and genotype distribution in 146 lung cancer patients was...
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