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Article

Modulation of T-cell receptor signal transduction by herpesvirus signaling adaptor protein.

Molecular and cellular biology - 1 Jun 2004

Lee Sun-Hwa, Chung Young-Hwa, Cho Nam-Hyuk, Gwack Yousang, Feng Pinghui, Jung Jae U

Abstract excerpt

Because of its central regulatory role, T-cell receptor (TCR) signal transduction is a common target of viruses. We report here the identification of a small signaling protein, ORF5, of the T-lymphotropic tumor virus herpesvirus saimiri (HVS). ORF5 is predicted to contain 89 to 91 amino acids with an amino-terminal myristoylation site and six SH2 binding motifs, showing structural similarity to cellular LAT...

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Identifiers

PMID: 15169900
DOI: 10.1128/MCB.24.12.5369-5382.2004
PMCID: PMC419894

Genes

LAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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