Article
The Product of the Herpesvirus saimiri Open Reading Frame 1 (Tip) Interacts with T Cell-specific Kinase p56lck in Transformed Cells
1 Mar 1995
Abstract excerpt
Subgroup C strains of Herpesvirus saimiri, a leukemogenic virus of non-human primates, transform human T cells to permanent growth in culture. These cell retain their antigen specificity, and they are becoming widely used as a model for activated human T cells. Though a variety of human cell types can be infected by H. saimiri, transformation appears to be specific for CD4+ and CD8+ T cells. Our investigation of...
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