Article

Transcription factor NF-κB in a basal metazoan, the sponge, has conserved and unique sequences, activities, and regulation

2019-07-02

Abstract excerpt

<h4>ABSTRACT</h4> Biological and biochemical functions of immunity transcription factor NF-κB in basal metazoans are largely unknown. Herein, we characterize transcription factor NF-κB from the demosponge Amphimedon queenslandica (Aq), in the phylum Porifera. Structurally and phylogenetically, the Aq-NF-κB protein is most similar to NF-κB p100 and p105 among vertebrate proteins, with an N-terminal DNA-binding/di...

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Literature Corpus work: 9de7f89d-0215-548a-8f40-4e3a61ae7b53
DOI: 10.1101/691097

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