Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tbx2/3 is an essential mediator within the Brachyury gene network during Ciona notochord development.

Development (Cambridge, England) - 1 Jun 2013

José-Edwards Diana S, Oda-Ishii Izumi, Nibu Yutaka, Di Gregorio Anna

Abstract excerpt

T-box genes are potent regulators of mesoderm development in many metazoans. In chordate embryos, the T-box transcription factor Brachyury (Bra) is required for specification and differentiation of the notochord. In some chordates, including the ascidian Ciona, members of the Tbx2 subfamily of T-box genes are also expressed in this tissue; however, their regulatory relationships with Bra and their contributions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brachyury Protein
Share to Cell Lineage
Share to Fetal Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Regulatory Networks

Share to In Situ Hybridization

Share to Notochord

Share to T-Box Domain Proteins

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 23674602
DOI: 10.1242/dev.094227
PMCID: PMC3653562

Genes

MLKL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tbx2/3 is an essential mediator within the Brachyury gene network during Ciona notochord development.PMID 23674602Read ↗

The evolutionarily conserved leprecan gene: its regulation by Brachyury and its role in the developing Ciona notochord.Semantic proximity Read ↗

Conserved enhancer logic controls the notochord expression of vertebrate <i>Brachyury</i>Semantic proximity Read ↗

Diverse logics and grammar encode notochord enhancersSemantic proximity Read ↗

Putative oncogene Brachyury ( T ) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMTSemantic proximity Read ↗

Notochord and axial progenitor generation by timely BMP and NODAL inhibition during vertebrate trunk formationSemantic proximity Read ↗

Transcriptional Profiling Supports the Notochordal Origin of Chordoma and Its Dependence on a TGFB1-TBXT NetworkSemantic proximity Read ↗

Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival.Semantic proximity Read ↗

Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord.Semantic proximity Read ↗

An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm.Semantic proximity Read ↗

In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome.Semantic proximity Read ↗

Coquillette, a sea urchin T-box gene of the Tbx2 subfamily, is expressed asymmetrically along the oral-aboral axis of the embryo and is involved in skeletogenesis.Semantic proximity Read ↗

Molecular identification of spadetail: regulation of zebrafish trunk and tail mesoderm formation by T-box genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.