Article
Enhanced APOE2 transmission rates in families with autistic probands.
Psychiatric genetics - 1 Jun 2004
Persico A M, D'Agruma L, Zelante L, Militerni R, Bravaccio C, Schneider C, Melmed R, Trillo S, Montecchi F, Elia M, Palermo M, Rabinowitz D, Pascucci T, Puglisi-Allegra S, Reichelt K-L, Muscarella L, Guarnieri V, Melgari J-M, Conciatori M, Keller F
Abstract excerpt
We have previously described linkage/association between reelin gene polymorphisms and autistic disorder. APOE also participates in the Reelin signaling pathway, by competitively antagonizing Reelin binding to APOE receptor 2 and to very-low-density lipoprotein receptors. The APOE2 protein variant displays the lowest receptor binding affinity compared with APOE3 and APOE4. In this study, we assess...
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