Article
Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder.
Molecular psychiatry - 1 Mar 2001
Persico A M, D'Agruma L, Maiorano N, Totaro A, Militerni R, Bravaccio C, Wassink T H, Schneider C, Melmed R, Trillo S, Montecchi F, Palermo M, Pascucci T, Puglisi-Allegra S, Reichelt K L, Conciatori M, Marino R, Quattrocchi C C, Baldi A, Zelante L, Gasparini P, Keller F
Abstract excerpt
Autistic disorder (MIM 209850) is currently viewed as a neurodevelopmental disease. Reelin plays a pivotal role in the development of laminar structures including the cerebral cortex, hippocampus, cerebellum and of several brainstem nuclei. Neuroanatomical evidence is consistent with Reelin involvement in autistic disorder. In this study, we describe several polymorphisms identified using RNA-SSCP and DNA...
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