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Article

Reduced Expression of Cytokeratin 20 in Colorectal Carcinomas With High Levels of Microsatellite Instability

17 May 2004

Abstract excerpt

High levels of microsatellite instability (MSI-H) result from abnormal nucleotide mismatch repair in a subset of sporadic colorectal carcinomas (CRC) and in most CRC of hereditary non-polyposis colorectal cancer syndrome. CRC with MSI-H have distinctive clinical-pathologic features, but the immunophenotype has not been studied extensively. We evaluated immunohistochemical expression of cytokeratin 7 (CK7),...

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PMID: 15166663
DOI: 10.1097/01.pas.0000126757.58474.12

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