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Article

Colorectal carcinomas with high microsatellite instability: defining a distinct immunologic and molecular entity with respect to prognostic markers.

Human pathology - 1 Dec 2000

Edmonston T B, Cuesta K H, Burkholder S, Barusevicius A, Rose D, Kovatich A J, Boman B, Fry R, Fishel R, Palazzo J P

Abstract excerpt

Molecular analysis of hereditary nonpolyposis colorectal carcinomas (HNPCC) has identified DNA mismatch repair deficiencies with resulting microsatellite instability (MSI) as a pathway of carcinogenesis that appears to be relevant for prognosis, treatment, and possibly prevention. In this study, expression of cell cycle proteins and other known prognostic markers is correlated with the microsatellite status of...

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Source

Identifiers

PMID: 11150376
DOI: 10.1053/hupa.2000.20383

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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