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A <i>trans</i> -Complementing Recombination Trap Demonstrates a Low Propensity of Flaviviruses for Intermolecular Recombination

29 Oct 2009

Abstract excerpt

Intermolecular recombination between the genomes of closely related RNA viruses can result in the emergence of novel strains with altered pathogenic potential and antigenicity. Although recombination between flavivirus genomes has never been demonstrated experimentally, the potential risk of generating undesirable recombinants has nevertheless been a matter of concern and controversy with respect to the...

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PMID: 19864381
DOI: 10.1128/jvi.01063-09

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