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RNA recombination in pestiviruses: Cellular RNA sequences in viral genomes highlight the role of host factors for viral persistence and lethal disease

1 Mar 2011

Abstract excerpt

Persistence of the positive strand RNA virus bovine viral diarrhea virus (BVDV) in its host may last for years. However, it frequently ends in lethal disease triggered by emerging virus mutants created by RNA recombination. Those mutant genomes often encompass cellular mRNA fragments. Persistence of BVDV depends on a mechanism limiting viral RNA replication efficiency. This restriction is based on the dependency...

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PMID: 21358277
DOI: 10.4161/rna.8.2.14514

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