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RNA Structural Elements Determine Frequency and Sites of Nonhomologous Recombination in an Animal Plus-Strand RNA Virus

26 Apr 2012

Abstract excerpt

For highly variable RNA viruses, RNA recombination significantly contributes to genetic variations which may lead to changes of virulence, adaptation to new hosts, escape from the host immune response, and emergence of new infectious agents. Using a system based on transfection of cells with synthetic nonreplicable subgenomic transcripts derived from bovine viral diarrhea virus (family Flaviviridae), the...

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PMID: 22532677
DOI: 10.1128/jvi.00864-12

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