Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Yeast Ras regulates the complex that catalyzes the first step in GPI-anchor biosynthesis at the ER.

Cell - 28 May 2004

Sobering Andrew K, Watanabe Reika, Romeo Martin J, Yan Benjamin C, Specht Charles A, Orlean Peter, Riezman Howard, Levin David E

Abstract excerpt

The yeast ERI1 gene encodes a small ER-localized protein that associates in vivo with GTP bound Ras2 in an effector loop-dependent manner. We showed previously that loss of Eri1 function results in hyperactive Ras phenotypes. Here, we demonstrate that Eri1 is a component of the GPI-GlcNAc transferase (GPI-GnT) complex in the ER, which catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Cell Wall
Share to Chitin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum

Share to Glycosylphosphatidylinositols

Share to Guanosine Triphosphate

Share to ras Proteins

Share to Saccharomyces cerevisiae Proteins

Source

Identifiers

PMID: 15163411
DOI: 10.1016/j.cell.2004.05.003

Genes

GPI
ERI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Yeast Ras regulates the complex that catalyzes the first step in GPI-anchor biosynthesis at the ER.PMID 15163411Read ↗

Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins.Semantic proximity Read ↗

Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum.Semantic proximity Read ↗

The ER-resident Ras Inhibitor 1 (Eri1) of <i>Candida albicans</i> inhibits hyphal morphogenesis via the Ras-independent cAMP-PKA pathwaySemantic proximity Read ↗

Gpi19, the Saccharomyces cerevisiae homologue of mammalian PIG-P, is a subunit of the initial enzyme for glycosylphosphatidylinositol anchor biosynthesis.Semantic proximity Read ↗

AtPGAP1 functions as a GPI inositol-deacylase required for efficient transport of GPI-anchored proteins.Semantic proximity Read ↗

The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component.Semantic proximity Read ↗

A defect in GPI synthesis as a suggested mechanism for the role of ARV1 in intellectual disability and seizures.Semantic proximity Read ↗

Specific requirements for the ER to Golgi transport of GPI-anchored proteins in yeast.Semantic proximity Read ↗

PER1 is required for GPI-phospholipase A2 activity and involved in lipid remodeling of GPI-anchored proteins.Semantic proximity Read ↗

MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast.Semantic proximity Read ↗

Complementation analysis reveals a potential role of human ARV1 in GPI anchor biosynthesis.Semantic proximity Read ↗

GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.