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Article

Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins.

The Journal of cell biology - 1 May 1995

Hamburger D, Egerton M, Riezman H

Abstract excerpt

Anchoring of proteins to membranes by glycosylphosphatidylinositols (GPIs) is ubiquitous among all eukaryotes and heavily used by parasitic protozoa. GPI is synthesized and transferred en bloc to form GPI-anchored proteins. The key enzyme in this process is a putative GPI:protein transamidase that would cleave a peptide bond near the COOH terminus of the protein and attach the GPI by an amide linkage. We have...

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Source

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Identifiers

PMID: 7730400
DOI: 10.1083/jcb.129.3.629
PMCID: PMC2120449

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins.PMID 7730400Read ↗

The Schizosaccharomyces pombe GPI8 gene complements a Saccharomyces cerevisiae GPI8 anchoring mutant.Semantic proximity Read ↗

GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor.Semantic proximity Read ↗

Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins.Semantic proximity Read ↗

Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum.Semantic proximity Read ↗

Specific requirements for the ER to Golgi transport of GPI-anchored proteins in yeast.Semantic proximity Read ↗

Generating anchors only to lose them: The unusual story of glycosylphosphatidylinositol anchor biosynthesis and remodeling in yeast and fungi.Semantic proximity Read ↗

Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins.Semantic proximity Read ↗

Human PIG-U and Yeast Cdc91p Are the Fifth Subunit of GPI Transamidase That Attaches GPI-Anchors to ProteinsSemantic proximity Read ↗

AtPGAP1 functions as a GPI inositol-deacylase required for efficient transport of GPI-anchored proteins.Semantic proximity Read ↗

Plant glycosylphosphatidylinositol anchored proteins at the plasma membrane-cell wall nexus.Semantic proximity Read ↗

The GPI1 homologue from Plasmodium falciparum complements a Saccharomyces cerevisiae GPI1 anchoring mutant.Semantic proximity Read ↗

Gpi1, a Saccharomyces cerevisiae protein that participates in the first step in glycosylphosphatidylinositol anchor synthesis.Semantic proximity Read ↗

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