GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor.

doi:10.1091/mbc.e06-02-0104

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Article

GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor.

Molecular biology of the cell - 1 Jun 2006

Bosson Régine, Jaquenoud Malika, Conzelmann Andreas

Abstract excerpt

The anchors of mature glycosylphosphatidylinositol (GPI)-anchored proteins of Saccharomyces cerevisiae contain either ceramide or diacylglycerol with a C26:0 fatty acid in the sn2 position. The primary GPI lipid added to newly synthesized proteins in the ER consists of diacylglycerol with conventional C16 and C18 fatty acids. Here we show that GUP1 is essential for the synthesis of the C26:0-containing...

Topics

Acyltransferases
Amino Acid Sequence
Kinetics
Lipids
Membrane Transport Proteins
Molecular Sequence Data
Mutation
Plasmids
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Sequence Homology, Amino Acid

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PMID: 16597698
DOI: 10.1091/mbc.e06-02-0104
PMCID: PMC1474799

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