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The ER-resident Ras Inhibitor 1 (Eri1) of <i>Candida albicans</i> inhibits hyphal morphogenesis via the Ras-independent cAMP-PKA pathway

2024-02-28

Abstract excerpt

Ras signaling and glycosylphosphatidylinositol (GPI) biosynthesis are mutually inhibitory in S. cerevisiae . The inhibition is mediated via an interaction of yeast Ras2 with the Eri1 subunit of its GPI- N -acetylglucosaminyl transferase (GPI-GnT), the enzyme catalyzing the very first GPI biosynthetic step. In contrast, Ras signaling and GPI biosynthesis in C. albicans are mutually activated and together control...

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Literature Corpus work
58edfb52-7562-57db-9ad8-04f721bbf65b
DOI
10.1101/2024.02.28.582498
Open publication

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The ER-resident Ras Inhibitor 1 (Eri1) of <i>Candida albicans</i> inhibits hyphal morphogenesis via the Ras-independent cAMP-PKA pathwayDOI 10.1101/2024.02.28.582498
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