Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NIMA related kinase 2 promotes gastric cancer cell proliferationviaERK/MAPK signaling

19 Jun 2019

Abstract excerpt

BACKGROUND: NIMA related kinase 2 (NEK2) is closely related to mitosis, and it is currently considered to be over-expressed frequently in many poorly prognostic cancers. However, the effect of the up-regulated NEK2 on cellular signaling in tumors, such as gastric cancer (GC), is con-fusing. AIM: To determine the role of the up-regulation of NEK2 in GC. METHODS: To investigate the pathological significance of NEK2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to FOXO transcription factor regulation
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31249448
DOI: 10.3748/wjg.v25.i23.2898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NIMA related kinase 2 promotes gastric cancer cell proliferationviaERK/MAPK signalingPMID 31249448Read ↗

NEK2 Promotes ESCC Malignant Progression by Inhibiting Cellular Senescence via the FOXM1/c‐Myc/p27 Signaling PathwaySemantic proximity Read ↗

NIMA-related kinase 2 regulates hepatocellular carcinoma cell growth and proliferationSemantic proximity Read ↗

NEK2 Promotes the Migration, Invasion, Proliferation and Drug Resistance of ESCC Through the E2F1-IGF2 PathwaySemantic proximity Read ↗

Targeting NEK2 as a promising therapeutic approach for cancer treatmentSemantic proximity Read ↗

The NIMA-related kinase family and cancerSemantic proximity Read ↗

Upregulation of NEK2 is associated with drug resistance in ovarian cancerSemantic proximity Read ↗

NEK2 is a potential pan-cancer biomarker and immunotherapy targetSemantic proximity Read ↗

A Comprehensive Analysis Revealing NEK2 as an oncogene in the Tumor MicroenvironmentSemantic proximity Read ↗

NEK2 could act as a circadian time-dependent tumor suppressor gene and biomarker in esophageal squamous cell carcinomaSemantic proximity Read ↗

NIMA-Related Kinase 6 as an Effective Target Inhibits the Hepatocarcinogenesis and Progression of Hepatocellular CarcinomaSemantic proximity Read ↗

NEK2 Promotes Cell Proliferation and Glycolysis by Regulating PKM2 Abundance via Phosphorylation in Diffuse Large B-Cell LymphomaSemantic proximity Read ↗

Overexpression of NELFE contributes to gastric cancer progression via Wnt/β-catenin signaling-mediated activation of CSNK2B expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.