Article
Polymorphisms for microsomal epoxide hydrolase and genetic susceptibility to COPD.
International journal of molecular medicine - 1 Mar 2005
Park Jong Y, Chen Lan, Wadhwa Nina, Tockman Melvyn S
Abstract excerpt
Although smoking is the major causal factor in the development of chronic obstructive pulmonary disease (COPD), only 10-20% of chronic heavy cigarette smokers develop symptomatic COPD, which suggests the presence of genetic susceptibility. The human microsomal epoxide hydrolase (EH) is a metabolizing enzyme which involves the process of numerous reactive epoxide intermediates and contains polymorphic alleles...
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