Article
Microsomal epoxide hydrolase genotypes and chronic obstructive pulmonary disease in Japanese.
International journal of molecular medicine - 1 Jan 2000
Yoshikawa M, Hiyama K, Ishioka S, Maeda H, Maeda A, Yamakido M
Abstract excerpt
Polymorphisms in the gene for microsomal epoxide hydrolase (mEPHX), an enzyme involved in the protective mechanism against oxidative stress, have been reported to be associated with individual susceptibility to the development of chronic obstructive pulmonary disease (COPD). The polymorphisms in exons 3 and 4 in the mEPHX gene were examined in a total of 358 Japanese individuals, including 40 patients with COPD...
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