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Genetic tumor markers with prognostic impact in Dukes' stages B and C colorectal cancer patients.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Mar 2003

Diep Chieu B, Thorstensen Lin, Meling Gunn Iren, Skovlund Eva, Rognum Torleiv O, Lothe Ragnhild A

Abstract excerpt

PURPOSE: To examine several genetic changes in primary colorectal carcinomas (CRCs) from patients with 10 years of follow-up and associate the findings with clinicopathologic variables. MATERIAL AND METHODS: DNA from 220 CRCs were analyzed for allelic imbalances at 12 loci on chromosome arms 1p, 14q, 17p, 18q, and 20q, and the microsatellite instability (MSI) status was determined. The clinical significance of...

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PMID: 12610180
DOI: 10.1200/JCO.2003.05.190

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