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Article

Defining the oncogenic function of the TEL/AML1 (ETV6/RUNX1) fusion protein in a mouse model.

Oncogene - 17 Nov 2005

Fischer Meike, Schwieger Maike, Horn Stefan, Niebuhr Birte, Ford Anthony, Roscher Susanne, Bergholz Ulla, Greaves Mel, Löhler Jürgen, Stocking Carol

Abstract excerpt

The t(12;21) translocation, generating the TEL/AML1 fusion protein, is the most common genetic lesion in childhood cancer. Using a bone marrow transplantation model, we demonstrate that TEL/AML1 expression impinges on normal hematopoietic differentiation, leading to the in vivo accumulation and p...

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Topics

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Share to Bone Marrow Transplantation
Share to Chromosomes, Human, Pair 12
Share to Chromosomes, Human, Pair 21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 2 Subunit

Share to Hematopoietic Stem Cells

Share to Oncogene Proteins, Fusion

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Translocation, Genetic

Source

Identifiers

PMID: 16044150
DOI: 10.1038/sj.onc.1208931

Genes

ETV6
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16044150-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Defining the oncogenic function of the TEL/AML1 (ETV6/RUNX1) fusion protein in a mouse model.PMID 16044150Read ↗

Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice.Semantic proximity Read ↗

The Second Oncogenic Hit Determines the Cell Fate of ETV6-RUNX1 Positive LeukemiaSemantic proximity Read ↗

Modeling the evolution of ETV6-RUNX1–induced B-cell precursor acute lymphoblastic leukemia in miceSemantic proximity Read ↗

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The TEL-AML1 leukemia fusion gene dysregulates the TGF-β pathway in early B lineage progenitor cellsSemantic proximity Read ↗

Initially disadvantaged, TEL-AML1 cells expand and initiate leukemia in response to irradiation and cooperating mutationsSemantic proximity Read ↗

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia.Semantic proximity Read ↗

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The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cellsSemantic proximity Read ↗

TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemiaSemantic proximity Read ↗

ETV6/RUNX1 Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic LeukaemiaSemantic proximity Read ↗

Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.Semantic proximity Read ↗

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