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Characterization of p190-Bcr-Abl chronic myeloid leukemia reveals specific signaling pathways and therapeutic targets

9 Nov 2020

Abstract excerpt

Abstract The oncogenic protein Bcr-Abl has two major isoforms, p190Bcr-Abland p210Bcr-Abl. While p210Bcr-Ablis the hallmark of chronic myeloid leukemia (CML), p190Bcr-Abloccurs in the majority of Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) patients. In CML, p190Bcr-Abloccurs in a minority of patients associating with distinct hematological features and inferior outcomes, yet the pathogenic role...

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PMID: 33168949
DOI: 10.1038/s41375-020-01082-4

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