Article
The interleukin-6-174 promoter polymorphism is associated with a risk of development of Kaposi's sarcoma in renal transplant recipients.
Anticancer research - 1 Jan 2000
Gazouli Maria, Zavos George, Papaconstantinou Ioannis, Lukas John C, Zografidis Anastassios, Boletis John, Kostakis Alkiviadis
Abstract excerpt
BACKGROUND: Kaposi's sarcoma (KS), an angio-proliferative inflammation lesion, is frequently secondary to clinical immunosuppression such as after renal transplantation. KS growth is promoted by the inflammatory cytokine interleukin-6 (IL-6) and is also correlated with human herpesvirus-8 (HHV-8) infection. MATERIALS AND METHODS: In a sample of 15 renal transplant patients with KS and 40 patients without KS, we...
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