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Article

A meta-analysis of the effects of interleukin-6 -174 G>C genetic polymorphism on acute graft-versus-host disease susceptibility.

Clinical therapeutics - 1 Feb 2012

Choi Boyoon, Lee Dong Eun, Park Hyo Young, Jeong Sohyun, Lee Sang-Min, Ji Eunhee, Park Seonyang, Oh Jung Mi

Abstract excerpt

BACKGROUND: The interleukin-6 (IL-6) -174 G>C genetic polymorphism has been implicated to play an important role in acute graft-versus-host disease (aGVHD). However, previous studies have yielded inconclusive results as to its role in patient susceptibility to aGVHD, and no study to date has systematically analyzed this polymorphism. OBJECTIVE: A meta-analysis of the published evidence was conducted to estimate...

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PMID: 22304944
DOI: 10.1016/j.clinthera.2012.01.010

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