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Article

The Normal Response to RAS: Senescence or Transformation?

1 Jun 2004

Abstract excerpt

Normal cells are thought to protect against transformation by undergoing a permanent cell cycle arrest, cellular senescence, in response to the expression of activated oncogenes such as RAS. We recently found that freshly established neonatal human fibroblasts are resistant to RAS-induced senescence. Moreover, extended passaging of normal fibroblasts leads to increased levels of the cyclin dependent kinase...

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Identifiers

PMID: 15153805
DOI: 10.4161/cc.3.6.948

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