Article
Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration.
Scientific reports - 16 Aug 2017
Wu Wei, Hale Alexander James, Lemeer Simone, den Hertog Jeroen
Abstract excerpt
Zebrafish have the capacity to regenerate lost tissues and organs. Amputation of the caudal fin results in a rapid, transient increase in H2O2 levels emanating from the wound margin, which is essential for regeneration, because quenching of reactive oxygen species blocks regeneration. Protein-tyrosine phosphatases (PTPs) have a central role in cell signalling and are susceptible to oxidation, which results in...
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