Article
The allelic variant of LAR gene promoter -127 bp T-->A is associated with reduced risk of obesity and other features related to insulin resistance.
Journal of molecular medicine (Berlin, Germany) - 1 Jul 2004
Miscio Giuseppe, Tassi Vittorio, Coco Angelo, Soccio Teresa, Di Paola Rosa, Prudente Sabrina, Baratta Roberto, Frittitta Lucia, Ludovico Ornella, Padovano Libera, Dallapiccola Bruno, Di Mario Umberto, De Cosmo Salvatore, Trischitta Vincenzo
Abstract excerpt
Insulin resistance, which is pathogenic for type 2 diabetes (T2D), is under the control of largely unknown genetic determinants. LAR, a protein-tyrosine phosphatase which inhibits insulin signalling, is overexpressed in animal and human models of insulin resistance. We studied the entire sequence of the LAR gene by SSCP analysis and automatic DNA sequencing, with the aim of verifying whether its sequence variants...
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