Article
A C/T single nucleotide polymorphism at the tyrosine kinase domain of the insulin receptor gene is associated with polycystic ovary syndrome.
Fertility and sterility - 1 Dec 2002
Siegel Sheera, Futterweit Walter, Davies Terry F, Concepcion Erlinda S, Greenberg David A, Villanueva Ronald, Tomer Yaron
Abstract excerpt
OBJECTIVE: To examine whether the insulin receptor (INSR) gene contributes to genetic susceptibility to the polycystic ovary syndrome (PCOS). DESIGN: Case-control study. SETTING: Academic endocrinology clinic. PATIENT(S): Ninety-nine women with PCOS as defined by the National Institutes of Health consensus and polycystic ovaries on ultrasonography, and 136 healthy controls. MAIN OUTCOME MEASURE: Frequency of...
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