Differential effect of immune cells on non‐pathogenic Gram‐negative bacteria‐induced nuclear factor‐κB activation and pro‐inflammatory gene expression in intestinal epithelial cells

Abstract excerpt

We have previously shown that non-pathogenic Gram negative bacteria induce RelA phosphorylation, nuclear factor (NF)-kappaB transcriptional activity and pro-inflammatory gene expression in intestinal epithelial cells (IEC) in vivo and in vitro. In this study, we investigated the molecular mechanism of immune-epithelial cell cross-talk on Gram-negative enteric bacteria-induced NF-kappaB signalling and...

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