Intestinal epithelial cell signalling and host‐derived negative regulators under chronic inflammation: to be or not to be activated determines the balance towards commensal bacteria

Abstract excerpt

Advancing knowledge regarding the cellular mechanisms of intestinal inflammation has led to a better understanding of the disease pathology in patients with chronic disorders of the gut including inflammatory bowel disease, coeliac disease, lymphocytic colitis and irritable bowel syndrome. An emerging new paradigm suggests that changes in the homeostasis of bacteria- and host-derived signal transduction at the...

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