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Article

The IκB/NF-κB system: a key determinant of mucosal inflammation and protection

1 Mar 2000

Abstract excerpt

The ubiquitous transcription factor NF-kappa B is a central regulator of the transcriptional activation of a number of genes involved in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth. Induction of these genes in intestinal epithelial cells (IECs) by activated NF-kappa B profoundly influences mucosal inflammation and repair. NF-kappa B activation requires the removal...

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PMID: 10712233
DOI: 10.1152/ajpcell.2000.278.3.c451

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