Article
Host gene expression in the colon of gnotobiotic interleukin-2-deficient mice colonized with commensal colitogenic or noncolitogenic bacterial strains: common patterns and bacteria strain specific signatures.
Inflammatory bowel diseases - 1 Sept 2006
Bohn Erwin, Bechtold Oliver, Zahir Naima, Frick Julia-Stefanie, Reimann Jörg, Jilge Burghart, Autenrieth Ingo B
Abstract excerpt
BACKGROUND: Specific pathogen-free (SPF), but not germfree (GF), interleukin (IL)-2-deficient (IL-2-/-) mice develop inflammatory bowel disease (IBD) at 10 to 15 weeks of age. Gnotobiotic IL-2-/- mice monocolonized with E. coli mpk develop IBD at 25 to 33 weeks of age but not B. vulgatus mpk, E. coli Nissle 1917, or mice cocolonized with both E. coli mpk and B. vulgatus. METHODS: To determine genes regulated by...
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