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Article

Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination

1 Sept 2000

Abstract excerpt

Epithelia of the vertebrate intestinal tract characteristically maintain an inflammatory hyporesponsiveness toward the lumenal prokaryotic microflora. We report the identification of enteric organisms (nonvirulent Salmonella strains) whose direct interaction with model human epithelia attenuate synthesis of inflammatory effector molecules elicited by diverse proinflammatory stimuli. This immunosuppressive effect...

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PMID: 10968793
DOI: 10.1126/science.289.5484.1560

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