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Article

Solution structure and backbone dynamics of the K18G/R82E Alicyclobacillus acidocaldarius thioredoxin mutant: a molecular analysis of its reduced thermal stability.

Biochemistry - 25 May 2004

Leone Marilisa, Di Lello Paola, Ohlenschläger Oliver, Pedone Emilia M, Bartolucci Simonetta, Rossi Mosè, Di Blasio Benedetto, Pedone Carlo, Saviano Michele, Isernia Carla, Fattorusso Roberto

Abstract excerpt

No general strategy for thermostability has been yet established, because the extra stability of thermophiles appears to be the sum of different cumulative stabilizing interactions. In addition, the increase of conformational rigidity observed in many thermophilic proteins, which in some cases disappears when mesophilic and thermophilic proteins are compared at their respective physiological temperatures,...

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PMID: 15147188
DOI: 10.1021/bi036261d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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