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Article

An integrated structural and computational study of the thermostability of two thioredoxin mutants from Alicyclobacillus acidocaldarius.

Journal of bacteriology - 1 Jul 2003

Bartolucci Simonetta, De Simone Giuseppina, Galdiero Stefania, Improta Roberto, Menchise Valeria, Pedone Carlo, Pedone Emilia, Saviano Michele

Abstract excerpt

We report a crystallographic and computational analysis of two mutant forms of the Alicyclobacillus acidocaldarius thioredoxin (BacTrx) done in order to evaluate the contribution of two specific amino acids to the thermostability of BacTrx. Our results suggest that the thermostability of BacTrx may be modulated by mutations affecting the overall electrostatic energy of the protein.

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Source

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Identifiers

PMID: 12837806
DOI: 10.1128/JB.185.14.4285-4289.2003
PMCID: PMC164891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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