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Article

Roles of stem cell factor/c-Kit and effects of Glivec/STI571 in human uveal melanoma cell tumorigenesis.

The Journal of biological chemistry - 23 Jul 2004

Lefevre Gaëlle, Glotin Anne-Lise, Calipel Armelle, Mouriaux Frédéric, Tran Thi, Kherrouche Zoulika, Maurage Claude-Alain, Auclair Christian, Mascarelli Frédéric

Abstract excerpt

The B-Raf(V599E)-mediated constitutive activation of ERK1/2 is involved in establishing the transformed phenotype of some uveal melanoma cells (Calipel, A., Lefevre, G., Pouponnot, C., Mouriaux, F., Eychene, A., and Mascarelli, F. (2003) J. Biol. Chem. 278, 42409-42418). We have shown that stem cell factor (SCF) is involved in the proliferation of normal uveal melanocytes and that c-Kit is expressed in 75% of...

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Identifiers

PMID: 15145934
DOI: 10.1074/jbc.M403907200

Genes

KIT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Roles of stem cell factor/c-Kit and effects of Glivec/STI571 in human uveal melanoma cell tumorigenesis.PMID 15145934Read ↗

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